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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXT1
All Species:
23.03
Human Site:
Y117
Identified Species:
42.22
UniProt:
Q16394
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16394
NP_000118.2
746
86255
Y117
K
K
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108202
675
74245
A73
E
D
A
A
S
P
Q
A
P
H
G
G
S
C
N
Dog
Lupus familis
XP_539145
746
86191
Y117
K
K
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P97464
746
86289
Y117
K
K
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Rat
Rattus norvegicus
NP_001101455
670
74649
Q68
N
P
E
E
D
V
Q
Q
L
P
R
V
S
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509292
443
50957
Chicken
Gallus gallus
XP_418396
865
98072
Y236
Q
K
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Frog
Xenopus laevis
NP_001083782
738
84810
Y109
R
R
N
G
F
K
V
Y
I
Y
P
Q
Q
K
G
Zebra Danio
Brachydanio rerio
Q5IGR7
741
85103
Y112
Q
R
N
G
F
K
V
Y
V
Y
P
Q
Q
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V730
760
87290
P113
V
Y
I
Y
P
P
E
P
L
N
S
L
G
A
A
Honey Bee
Apis mellifera
XP_391845
711
82974
K106
V
I
S
P
L
Y
Q
K
I
L
N
V
I
T
E
Nematode Worm
Caenorhab. elegans
O01704
378
44434
Sea Urchin
Strong. purpuratus
XP_783281
693
79753
Y91
T
S
I
R
A
S
R
Y
F
T
T
N
A
D
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
43.9
99.1
N.A.
99.3
42.3
N.A.
58
78.2
88.4
83.6
N.A.
54.4
55.6
26.2
52.1
Protein Similarity:
100
N.A.
60.4
99.5
N.A.
99.7
58.7
N.A.
58.9
81
94.2
91.9
N.A.
69.8
70.2
37.4
68.2
P-Site Identity:
100
N.A.
0
100
N.A.
100
6.6
N.A.
0
93.3
80
86.6
N.A.
0
0
0
6.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
20
N.A.
0
100
100
100
N.A.
6.6
13.3
0
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
0
8
0
0
0
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
0
0
8
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
8
0
8
8
0
0
8
0
0
0
0
0
0
0
16
% E
% Phe:
0
0
0
0
47
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
47
0
0
0
0
0
0
8
8
8
0
54
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
16
0
0
0
0
0
16
0
0
0
8
0
0
% I
% Lys:
24
31
0
0
0
47
0
8
0
0
0
0
0
47
0
% K
% Leu:
0
0
0
0
8
0
0
0
16
8
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
47
0
0
0
0
0
0
8
8
8
0
0
8
% N
% Pro:
0
8
0
8
8
16
0
8
8
8
47
0
0
0
0
% P
% Gln:
16
0
0
0
0
0
24
8
0
0
0
47
47
0
0
% Q
% Arg:
8
16
0
8
0
0
8
0
0
0
8
0
0
8
0
% R
% Ser:
0
8
8
0
8
8
0
0
0
0
8
0
16
0
0
% S
% Thr:
8
0
0
0
0
0
0
0
0
8
8
0
0
8
0
% T
% Val:
16
0
0
0
0
8
47
0
39
0
0
16
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
8
0
54
0
47
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _